Frank’s Column
Frank’s Column
New Hope for Reversing Cognitive Decline; Senolytics
A definitive mouse study shows that several forms of stress increase multiplication rates of brain immune cells, leading to early senescence in those cell populations, and that leads to damage of neurons and cognitive decline, potentially including Parkinson's,...
The Promise of iPSC Vesicles for Vertebral Disk Repair
Take any old skin cell (or a million or so), add the four Yamanaka Factors reversing it's/their age to make it/them into near embryonic stem cells (induced pluripotent mesenchymal stem cells or iMSCs), feed them and let them multiply, then harvest the signaling...
The State of Senolytic Drug Development and Deployment
Senolytic drugs (or compounds) are a promising tool for reducing the impact of aging, potentially pushing the onset of the diseases of aging out into the far future. So how far along are we to deploying this potential tool for the average citizen's benefit? There are...
A Comprehensive Longevity Supplement Worth Considering – “Core” by Novos Labs
There are many individual supplements on the market claiming to promote Longevity and extended Healthspan, but I have been waiting for a product that would package key nutrients known to synergistically thwart the significant aging mechanisms at a reasonable price....
Definitive Science on Covid-19 and Benefit of Vitamin D Supplementation
I've been harping loud and long about supplementing vitamin D3 for optimal aging and for preventing severe damage or death from Covid-19. I typically use 5000-10,000 IU in summer, (because I don't get much sun) and 15,000 to 20,000 IU in winter, and have been doing so...
An Update on Cartilage Repair
Can an 81 year old gym rat regrow knee cartilage? It seems so. In July 2020, I was ramping up my leg-press load to see if I could get back to 10 plates per side (1000 lb including the sled). When I got to 8 plates per side on my last set that day, my left knee really...
Decades More Health-Span Possible with Frank’s Coaching at Fitness19, Simi Valley
Frank Wilhelmi: Senior Fitness Specialist & Trainer Exercise Training to build Muscle/Strength, Vaporize Fat, Boost Stamina - Move with Grace and Ease Diet/Nutrition - for Optimal Health, Fitness & Longevity Supplements - to Counter Functional Losses of Aging,...
Update on Potential Prostate Cancer Treatement
On September 18, 2019 I had an MRI that found two suspicious loci in my prostate, one of which was diagnosed as likely stage 1 Prostate cancer and the other as transitional, I chose to try an underground approach shown to be selective at killing cancer cells via 4...
Senolytic Therapy Improves Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy is well known for causing peripheral neuropathy - a tingling or burning in the hands and feet or perhaps simply numbness in extremities. Now there is evidence that this is caused by Cisplatin and other chemo-drugs inducing a state of senescent-like injury...
Study finds Hydroxychloroquine Reduces in-Hospital COVID-19 Mortality
August 25, 2020 Study finds hydroxychloroquine reduces in-hospital COVID-19 mortality by Istituto Neurologico Mediterraneo Neuromed I.R.C.C.S. An Italian observational study contributes to the ongoing debate regarding the use of hydroxychloroquine in the current...