Frank’s Column

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Frank’s Column

This is where I keep you up to date on what I’m interested in, experimenting with or any other world-shaking undertaking I’m working on. My focus in life for Senior Fitness centers on the prospect of making it in great health past 120 yrs of age. I hope to keep readers up to date on what is working for me in this column.
New Hope for Reversing Cognitive Decline; Senolytics

New Hope for Reversing Cognitive Decline; Senolytics

A definitive mouse study shows that several forms of stress increase multiplication rates of brain immune cells, leading to early senescence in those cell populations, and that leads to damage of neurons and cognitive decline, potentially including Parkinson's,...

The Promise of iPSC Vesicles for Vertebral Disk Repair

The Promise of iPSC Vesicles for Vertebral Disk Repair

Take any old skin cell (or a million or so), add the four Yamanaka Factors reversing it's/their age to make it/them into near embryonic stem cells (induced pluripotent mesenchymal stem cells or iMSCs), feed them and let them multiply, then harvest the signaling...

The State of Senolytic Drug Development and Deployment

The State of Senolytic Drug Development and Deployment

Senolytic drugs (or compounds) are a promising tool for reducing the impact of aging, potentially pushing the onset of the diseases of aging out into the far future. So how far along are we to deploying this potential tool for the average citizen's benefit? There are...

An Update on Cartilage Repair

An Update on Cartilage Repair

Can an 81 year old gym rat regrow knee cartilage? It seems so. In July 2020, I was ramping up my leg-press load to see if I could get back to 10 plates per side (1000 lb including the sled). When I got to 8 plates per side on my last set that day, my left knee really...

My latest thinking about aging optimally; things we should be attending to with time, energy and money.

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