Restore Strength, Fitness, Function with Frank; Senior Specialist @ Island Health & Fitness, Simi Valley
Hire me, Frank Wilhelmi, Senior Fitness Specialist, BS, ME, CFT, as your Personal Trainer and I will give you skills to keep an aging body in top shape into your 80s, 90s and beyond! Let me (at 83) show you strategies that work life-long to sustain real long-term...
Sendoff for 2022
On this last day of 2022, I am in day 5 of my first Covid-19 infection, having finished day 3 of Paxlovid anti-viral therapeutic drug, and feeling very much like I have it beat. Within a half hour of the first dose the disease trajectory had reversed from rapid...
Update on My Strategies for Longevity
Here are two notable sources of technical stuff on NOT AGING, followed by supplements I use to aid in that effort: https://www.fightaging.org/: Written by a bright guy with the name Reason; he puts up three articles per week-day without fail. Format is: Study Title,...
Apigenin – A Promising Compound found in Chamomile and Parsley can Greatly Improve Health
I started looking (yet again) for ways to improve my sleep; to fall asleep faster and make sleep more restorative. Chamomile is noted for relaxation so I was looking for a stronger extract of chamomile or at least the sleep-inducing part of it, thought to be a...
Reality Check on Stem Cell Exosomes for Regeneration
I have high hopes that Stem Cell exosomes will prove to be the Thor's Hammer for regeneration and a tool for greatly extended lifespan. Like most hopes, realty is generally more complex than hope envisioned. Stewing up vast batches of stem cell exosomes to be used by...
Here is a surprising (to me) outcome of a mouse gut biome study that increases longevity and lowers inflammation in aged mice. Surprising because the presence of gram-negative bacteria, which normally increase inflammation because they constantly shed their highly...
A Good Cover Article on Klotho and Aging
In Greek Mythology Clotho is the one of the Three Fates or Moirai who spins the thread of human life; in our biology Klotho is a trans-membrane receptor structure, parts of which also circulate in our blood, that influences lifespan in many ways. For those who want to...
Update: Old vs Young Blood and Extra-Cellular Vesicles Carry Some of The Longevity Magic
Last year we learned that simply diluting old blood in the aged lets them function like younger (animals and humans) (Reference). Still, the search is continuing for youth factors in young blood that might also allow reversing some of aging. A new study has shown that...
Icariin Restores Gut Biome to Youthful Nature (In Old Mice)
Animal research shows that restoring the aged gut biome in old mice to that of a young one improves many measures of physical and mental capability, seemingly making the animal age in reverse. This has been accomplished by Fecal Transplantation (FT), by use of...
New Hope for Reversing Cognitive Decline; Senolytics
A definitive mouse study shows that several forms of stress increase multiplication rates of brain immune cells, leading to early senescence in those cell populations, and that leads to damage of neurons and cognitive decline, potentially including Parkinson's,...
The focus of SeniorFitness.com up til now has been on Strategies to Preserve Fitness into Advanced Age. Advanced Age is a comfortably ambiguous term that could apply to anyone stretching for a little more time on planet Earth without debilitating disabilities. The purposed goal in my mind was to stay “FIT” all the way up to the Point of Death, then quickly drop dead without a lot of fuss and pain.
The whole idea of slowly grinding to a pain-filled, function-less, several year dependency on others to clean me and change my diapers was and is highly repugnant. My understanding that “Everybody Dies” never disturbed me much, and after embracing the Catholic prospective of life’s purpose, troubled me even less. But I’m still of a mind that Later is Better with regard to end-of-life suffering; and I’d just rather not, if morally avoidable.
But what if we develop strategies to repair aging as we go along? What if we can get the body to just repair itself ad-infinitum, or at least for the next four decades or couple of centuries, and meanwhile preserve the physical and mental characteristics of a healthy 30 year-old, but able to grow from experience and accumulate all that wisdom and understanding. Would that be worth doing for you and me?
Many pathways to rejuvenation are being explored; here are some of the promising potential technologies that may result in practical strategies for extending life-span and health-span:
- supplements Glycation Breakers:
Glucose and other sugars accidentally bond to proteins and fats (glycation), destroying the function of those molecules, creating non-functional elements called Advanced Glycation End-products (AGEs) that stiffen tissues (such as artery walls) and excite the immune system, ramping up inflammation as we age. If we could develop glycation breakers that would uncouple these disruptive compounds, and allow them to be cleared from our systems, we would reverse many of the visible signs of aging and much of the limits to mobility seen with advanced age. The drug ALT711 promised to do this, but the developer went broke and the drug was abandoned. Glycation is a major mechanism of aging, and the ability to eliminate AGEs will reverse much of aging. No effective alternative has so far been developed.
- Blood Factors:
When the circulatory systems of young and old mice are cross-coupled (Parabiosis), the old mouse appears to get younger and the young mouse ages rapidly. Much research has been done to tease out the factors in blood that cause these changes. Is it youth factors in the young blood or “old” factors in old blood, or is it both? To date, no youth factors have been shown to make that happen. But a recent study showed that replacing 1/2 the plasma in old mice with saline and albumin resulted in rejuvenation to the same degree as Parabiosis. This seems to imply that if we clean out the “old” factors in blood we should regain at least some years of longevity. (Referenced Article) A more recent study explored the possibility that perhaps only the old albumin was the culprit, and found that replacing only 1/2 of the albumin with fresh, undamaged albumin (without replacing plasma) yielded the same result. (Referenced Article)
- Boosting NAD+:
Nicotinamide Adenine Dinucleotide (NAD+) is an enzyme required for energy production in all cells and catalyzes hundreds of metabolic reactions, and it declines with age. As a result, the rate of energy production, repair, healing etc. all decline with age as NAD+ is rationed to support the most immediate needs. Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (MNM) can both boost NAD+ levels back to youthful levels, and restore energy production like magic. I’ve been using NMN for about 6 years now and well into my 83rd year, never need a nap like when I was 75. This is a no-brainer if we can afford the fairly reasonable cost. My recommended source is Renue By Science: They pioneered science and developed the supplements for optimal results. This is one of the strategies available now to let you feel and function literally half your age! For a 10% discount, use discount code FRANK10 at check out.
- Senolytics and Senomorphics:
Cellular senescence is a major cause and mechanism of aging. Senescent cells are not passive, idle passengers for life, but can be more like Zombies, adopting a Senescent-Associated-Secretory-Phenotype or SASP, secreting highly damaging, pro-inflammatory signalling chemicals that disrupt surrounding tissues, melting connective tissues and inducing nearby cells to become senescent as well. Senolytics kill senescent cells while Senomorphics are able to restore normal function to some senescent cells; both reduce the impact of the SASP, which otherwise will lead to a fatal cascade of inflammation as the population of senescent cells accelerates. There are existing supplements which can be used as Senolytics and many drug companies are developing drugs for commercial use. Removing senescent cells periodically can perhaps let us live in good health for several decades longer.
- Stem Cells and Culture Medium:
Many clinics have been using stem cells (SCs) taken from our own body fat or bone marrow, cultured to grow in number, and reintroduced to our tissues that need repair, to maybe/maybe not effect an amazing repair. It’s kind of a crap shoot! Results are not always predictable. Over the years they found that the stem cells often did not integrate into the repair; a high percentage of the cells died off, but the repair still happened. The SCs secreted signalling chemicals that actually brought about the repair. Looking at the Medium the SCs were cultured in, they found Vesicles (microscopic membrane-enclosed bags) that SCs secrete held the stew of healing-promoting compounds. Contained in the Culture Medium, these vesicles are not tagged with any Me/Not-Me signal therefore don’t induce source-host rejection as SCs themselves would exhibit. Picture the possibility of vast SC-growing tanks of healthy SCs brewing vats of healing liquid, capable of repairing wide varieties of tissues, organs, joints – perhaps even brains. This may not be the outcome, but it sounds exciting.
- Mitochondrial Transfer:
Studies have shown that mitochondria migrate between cells when needed, have been harvested from cells, transferred to other cells, even between species of cells. Mitochondria are the organelles that generate nearly all of the energy to run life and metabolism of most living species. They have a fragile DNA of their own, inherited from the egg they arose from, a life span, a limited repair capability, and when enough of them die off as in aging, we do likewise. It might be a stretch to suggest that, like stem cells, we might be able to grow harvest-able quantities of free mitochondria and introduce them via IV or injection into our blood stream and coax them to repopulate our own aging cells, thereby regaining the energy production of our youth. Keep your eyes on this possibility – it begins to look possible.