I have written before about using Senolytic Activator from LifeExtension.com to kill off senescent cells. I had been using this strategy on a quarterly basis for about 4 years, and have increased the frequency recently to a monthly schedule. However, there has been long-standing concern that the use of Senolytics might result in damage to muscle fibers that the body would not be able to repair; that killing one or more senescent cells in a muscle fiber structure might result in permanent loss of that structure.
A recent study in mice shows that not to be the case and that elimination of senescent cells in muscle structure does not cause structural permanent damage, but improves the healing process associated with normal muscle operation. Treated mice lost less muscle volume than untreated mice with the passage of time, and saw improved fiber type distribution and strength more resembling youthful muscle structure. This is very good news!
Author comment from the study:
“What does seem clear is that whatever the answers to those questions, senolytic therapies are not inflicting any measurable harm on the muscles of older mice, and indeed are almost uniformly either preserving or improving muscle mass and function. That’s the most salient answer to our question, and fortunately it’s a reassuring one.”
Most studies to date on animals and humans have used the combination of Quercetin and the drug Dasatinib. Searching for a plant-based, non-prescription, substitute for Dasatinib, researchers found that polyphenols from black tea interact with the same Ephrin receptors that the drug interacts with in a similar Senolytic manner, albeit at higher dose. Life Extension’s Senolytic Activator uses Theaflavins for this function, along with Quercetin, Fisetin and Apigenin to kill senescent cells in a broad range of tissue types.
I use this product differently than the instructions on the bottle suggest, and I took that strategy from some of the early self-experimenter’s strategies: I take the bottle (36 capsules) in a 3-day period, taking 4 capsules three times a day on an empty stomach with an 8-oz. glass of water. When I first did this, I felt a touch of nausea starting about a day later, assuming it was a flood of dead cells bring processed, causing a flu-like symptom for a few hours. That only happened once; I never felt that again, so I assume I’m killing off fewer cells at a whack. I can’t prove that this is a “best way“ to use it, just my way. If you have kidney or liver issues you might want to start slower than I did, so the flood of dead cells is not an overload to those organs.
Use my affiliate link above to buy it if you feel like rewarding me for the info. I believe that anyone interested in staying fit longer and falling apart later should be using this strategy, available now, as opposed to waiting for the FDA to get around to approving a Drug to accomplish a similar outcome. Personally, I perceive no lost leg strength over the last ten years, and can do the same ‘leg press’ weights at 84 as I did at 74. I seem to be hanging together pretty well.
To Your Greater Health and Fitness,
Frank Wilhelmi – Retired/consultant electronic engineer researches and reports practical strategies for optimizing health and fitness into advanced age. “I have a passion for living life to the fullest, and helping others to do the same.” A rapidly growing body of knowledge now enables us to extend our health and fitness decades beyond popular expectations.