New Hope for Reversing Cognitive Decline; Senolytics
A definitive mouse study shows that several forms of stress increase multiplication rates of brain immune cells, leading to early senescence in those cell populations, and that leads to damage of neurons and cognitive decline, potentially including Parkinson's,...
Lifespan.io’s Graphic Page for Status of Rejuvenation Developments
For a quick update on virtually every technology being explored for repairing the damage of aging, take a look at Lifespan.io's awesome graphic page; The Rejuvenation Roadmap. The page show the status of pretty much every rejuvenation strategy in the works in a...
The Promise of iPSC Vesicles for Vertebral Disk Repair
Take any old skin cell (or a million or so), add the four Yamanaka Factors reversing it's/their age to make it/them into near embryonic stem cells (induced pluripotent mesenchymal stem cells or iMSCs), feed them and let them multiply, then harvest the signaling...
The State of Senolytic Drug Development and Deployment
Senolytic drugs (or compounds) are a promising tool for reducing the impact of aging, potentially pushing the onset of the diseases of aging out into the far future. So how far along are we to deploying this potential tool for the average citizen's benefit? There are...
A Comprehensive Longevity Supplement Worth Considering – “Core” by Novos Labs
There are many individual supplements on the market claiming to promote Longevity and extended Healthspan, but I have been waiting for a product that would package key nutrients known to synergistically thwart the significant aging mechanisms at a reasonable price....
Definitive Science on Covid-19 and Benefit of Vitamin D Supplementation
I've been harping loud and long about supplementing vitamin D3 for optimal aging and for preventing severe damage or death from Covid-19. I typically use 5000-10,000 IU in summer, (because I don't get much sun) and 15,000 to 20,000 IU in winter, and have been doing so...
Correlating the Onset of the Diseases of Aging with the Increase of Senescent Cell Population – Interesting!
A group of researchers has been building of model of aging, correlating the onset risk of the many diseases of aging (heart disease, cancers, dementias, organ failures, etc.) with with the now known increase of senescent cells as we age. When they tweek the variables...
An Update on Cartilage Repair
Can an 81 year old gym rat regrow knee cartilage? It seems so. In July 2020, I was ramping up my leg-press load to see if I could get back to 10 plates per side (1000 lb including the sled). When I got to 8 plates per side on my last set that day, my left knee really...
Year-end Review of the Scientific Progress in Fighting Aging
Here is a very exhaustive review of scientific progress aimed at arresting and reversing aging from our friend Reason at FightAging.org; not yet accomplished, but there are many promising pathways leading forward. A Look Back at 2020: Progress Towards the Treatment of...
Maintaining Muscle Mass into Advanced Age Reduces All-cause Mortality
The study that triggered this article is titled "Mechanisms by which Calorie Restriction Delays the Onset of Sarcopenia", which I think misses the point entirely. The article points out that CR is very effective at life extension in short-lived species, but not nearly...
Decades More Health-Span Possible with Frank’s Coaching at Fitness19, Simi Valley
Frank Wilhelmi: Senior Fitness Specialist & Trainer Exercise Training to build Muscle/Strength, Vaporize Fat, Boost Stamina - Move with Grace and Ease Diet/Nutrition - for Optimal Health, Fitness & Longevity Supplements - to Counter Functional Losses of Aging,...
Update on Plasma Dilution as a Regenerative Strategy to Mitigate/Reverse Aspects of Aging – A Pivotal Outcome
Diluting blood plasma in old mice (or people) by 50% restores youthful functions in a broad range of systems, in both body and brain!