Drugs or Supplements???
I personally am losing patience with the pace of release of products to fight or reverse aging. This is like swimming in molasses - really slow moving and expending tremendous energy (resources like money and more importantly time). The drawback for the Drug pathway...
Here is a surprising (to me) outcome of a mouse gut biome study that increases longevity and lowers inflammation in aged mice. Surprising because the presence of gram-negative bacteria, which normally increase inflammation because they constantly shed their highly...
Merry Christmas & Happy New Year Wishes – (Hopefully better than this one!!)
I just got back from my one-hour shift at the gym training my one client of the day (we closed early for Christmas), but let me tell you, I find this phase of my life the best yet. Yes some parts of this old body are not as functional as in my youth, but I am so...
A Good Cover Article on Klotho and Aging
In Greek Mythology Clotho is the one of the Three Fates or Moirai who spins the thread of human life; in our biology Klotho is a trans-membrane receptor structure, parts of which also circulate in our blood, that influences lifespan in many ways. For those who want to...
Update: Old vs Young Blood and Extra-Cellular Vesicles Carry Some of The Longevity Magic
Last year we learned that simply diluting old blood in the aged lets them function like younger (animals and humans) (Reference). Still, the search is continuing for youth factors in young blood that might also allow reversing some of aging. A new study has shown that...
Icariin Restores Gut Biome to Youthful Nature (In Old Mice)
Animal research shows that restoring the aged gut biome in old mice to that of a young one improves many measures of physical and mental capability, seemingly making the animal age in reverse. This has been accomplished by Fecal Transplantation (FT), by use of...
Icariin – Potential Super Supplement: Good For Everything?
Aging is accompanied by rising pain levels in practically everything in our bodies. Mine happens to be focused on knees and neck. That recently sent me to look into the ingredients of the well-advertised "Relief Factor". Of the four ingredients, the only one I was not...
Great article on the Benefits of Dance as an Exercise Strategy
One of the many newsletters I take had this very readable article on the benefits of taking a dance class for the purpose of exercise. Learning new steps with a favorite partner or a new one can improve the way the brain works and improve balance and motor control...
New Hope for Reversing Cognitive Decline; Senolytics
A definitive mouse study shows that several forms of stress increase multiplication rates of brain immune cells, leading to early senescence in those cell populations, and that leads to damage of neurons and cognitive decline, potentially including Parkinson's,...
Lifespan.io’s Graphic Page for Status of Rejuvenation Developments
For a quick update on virtually every technology being explored for repairing the damage of aging, take a look at Lifespan.io's awesome graphic page; The Rejuvenation Roadmap. The page show the status of pretty much every rejuvenation strategy in the works in a...
The Promise of iPSC Vesicles for Vertebral Disk Repair
Take any old skin cell (or a million or so), add the four Yamanaka Factors reversing it's/their age to make it/them into near embryonic stem cells (induced pluripotent mesenchymal stem cells or iMSCs), feed them and let them multiply, then harvest the signaling...
The State of Senolytic Drug Development and Deployment
Senolytic drugs (or compounds) are a promising tool for reducing the impact of aging, potentially pushing the onset of the diseases of aging out into the far future. So how far along are we to deploying this potential tool for the average citizen's benefit? There are...