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Resistance Exercise Reduces Cognitive Decline

Frank’s Comments:

This article (from May Life Extension Magazine) is must-know information if we hope to stay strong and smart up to our last days on earth. Strength Training is the most important form of exercise for we seniors – I Have been doing this for 45 years, and at 77 still love to push around significant weights. Read and Heed!!!

I have other Will Brink articles and courses on this site that you should check out both for bodybuilding and fat loss.

By Will Brink

When we think of the benefits of exercise, we tend to think of its ability to reduce cardiovascular disease, strengthen bones and muscles, and control weight.

Research is now proving that exercise is also crucial for preserving and enhancing brain function as we age.1-8

Studies show that exercise inhibits neurodegenerative diseases and even promotes neurogenesisthe creation of new brain cells.1-4

While most forms of exercise are associated with improved cognition, some forms may be superior to others in that respect. A newly released study demonstrates that resistance exercise or weight training, rather than aerobic exercise, has a greater impact on cognitive function.9

In this article, you will learn how exercise—especially strength-training exercise—can enhance cognition and memory and protect against age-related cognitive decline.

Enhanced Muscle Strength Provides Cognitive Protection

Cognitive Protection

For aging individuals, exercise is associated with an array of benefits that support longer lifespan.10 One recent study supports its connection to protecting and enhancing brain function.

In October 2016, scientists released the findings of a large randomized, double-blind, controlled trial that investigated the effects of resistance training on cognitive function in older adults.9 Resistance training, also called strength training, is exercise that uses weights, machines, bands, or other devices that work key muscle groups.

Previous studies had already shown the cognitive benefits of exercise, but this time the researchers wanted to determine whether the cognitive improvements occurred as a result of increased aerobic capacity or increased muscle strength.9

The study included 100 participants age 55 and over with mild cognitive impairment. Each was randomly assigned to either a sham version or a legitimate version of a progressive program of resistance training for two to three days per week. They also received computerized cognitive training.9

Although the program improved both whole-body muscle strength and aerobic capacity, the study team found that only the enhanced strength scores—but not the enhanced aerobic scores—were significantly associated with improvements in cognition.9

While the exact reason for these beneficial effects remains unknown, it is clear that it is the strength-related gains from resistance exercise that cause its cognitive benefits.9

This is an important finding that should change how the medical community approaches exercise. Most medical professionals recommend aerobic exercise, yet fail to understand the value and benefits of resistance exercise, especially in aging populations. This trial showing the superior cognitive benefits of strength training adds to a wealth of past evidence supporting the value of exercise in inhibiting sarcopenia, cognitive decline, and the onset of neurodegenerative disease.11-13

Data now conclusively show that exercise—specifically resistance training—is not just essential for the health of your body, but is an essential component to the health of your brain.

Exercise and the Brain

Exercise has been shown to be crucial for preserving, and even enhancing, brain function as we age. A Mayo Clinic study on more than 1,300 subjects concluded that any frequency of moderate-intensity exercise performed in midlife or late life was associated with reduced risk of having mild cognitive impairment.8

Multiple mechanisms for this cognitive benefit have been identified:

  • Exercise boosts blood flow in the brain,5,6 improving the delivery of oxygen and nutrients to critical brain cells.
  • Exercise promotes angiogenesis (the formation of new blood vessels from pre-existing vessels) as well as neurogenesis (the formation of new neurons from stem cells) in the adult hippocampus.2,3 Angiogenesis is important for neurogenesis because the improved blood supply facilitates the growth of new neurons and their supporting structures.2-4
  • Exercise enhances the production of key neurotransmitters, such as serotonin, acetylcholine, and gamma-aminobutyric acid (GABA).14 Serotonin regulates mood and sleep; acetylcholine plays a role in cognition, memory, and learning; and GABA, the main inhibitory neurotransmitter in the brain.15,16
  • Exercise also increases the production of beneficial brain proteins called neurotrophins (a family of proteins that regulate neuron survival).1,7 Greater physical activity can increase the production of a specific neurotrophin that is associated with enhanced cognitive function and brain plasticity.2,14,17,18
What You Need to Know
Inhibit Cognitive Decline with Resistance Exercise

Inhibit Cognitive Decline with Resistance Exercise

  • Although best-known for its cardiovascular benefits, exercise is also critical for preserving brain function in later life and reducing the risk of neurodegenerative diseases.
  • An exercise regimen even promotes the creation of new brain cells (neurogenesis).
  • New evidence documents that it is the boost in muscle strength resulting from resistance training that is responsible for this potent cognitive protection in older adults.
  • An array of natural supplements can enhance the powerful capacity of resistance training to preserve and enhance cognition.

Inhibiting Sarcopenia

Another key benefit of exercise is its ability to inhibit sarcopenia, the age-related loss of muscle mass, strength, and functionality. Sarcopenia not only robs elderly people of the ability to perform even the most basic tasks of daily living, but also vastly heightens their risk of suffering devastating injuries and even death from sudden falls and other accidents.

This condition generally appears after age 40 and accelerates after age 75 and can be caused by suboptimal hormone levels, inadequate dietary protein, other nutritional imbalances, oxidative stress, and inflammation. Most often, it is seen in physically inactive people.19,20

While all types of exercise are beneficial, scientists have determined that resistance or strength training provides superior protection against the advance of sarcopenia.

Resistance exercise stimulates the release of hormones that promote healthy muscle mass, including growth hormone (which is responsible for cell growth and regeneration throughout the body), as well as local growth factors such as mechano growth factor (which is important in helping muscles repair and grow).20,21 As an added benefit, these types of exercises can enhance the effects of other interventions, such as hormone replacement therapy.

While aerobic exercise is excellent for maintaining cardiovascular health and keeping body fat levels low, it is only mildly effective in preserving lean body mass. This explains why sarcopenia is not uncommon in endurance athletes as they age.

Resistance exercise, on the other hand, is essential for increasing—or even just preserving—lean body mass, which is especially critical for older adults. Strength training can also promote mobility, improve health-related fitness, and improve bone health.22

Nutrients That Boost Muscle Mass and Strength

Any good exercise regimen should be supported by key nutrients that help our bodies build and maintain muscle mass. The following nutrients have been shown to enhance the strength-boosting effects of resistance exercise—which, as we have learned, enhances cognition and memory, protects against age-related cognitive decline, and helps prevent sarcopenia.9


Whey protein is especially effective at preserving lean body mass in older adults.23 Whey protein augments the effects of resistance exercise training, especially if consumed shortly before or after exercise.24 Men who supplemented with whey in combination with resistance training showed improvements in one or more measures of muscle strength as well as lean tissue mass, compared to placebo recipients.25

Clinical studies indicate that older adults need greater amounts of high-quality protein than active, younger people, which means that the recommended daily protein intake may not be enough for older adults.26-29 So while the Institutes of Medicine recommends 0.8 grams per kilogram of body weight (or 58 grams for an aging adult weighing 160 pounds) for all adults, several studies suggest that healthy older adults need between 1.0-1.3 grams of protein per kilogram of body weight,10-12 (or 73-94 grams for an aging adult weighing 160 pounds).30-32



Athletes use creatine monohydrate to increase muscular force and power, reduce fatigue, and help increase muscle mass.33,34 Numerous studies have demonstrated that creatine supplementation increases strength and lean body mass in older adults who are participating in resistance exercise training.35-37 This may be due to the fact that the muscle fibers most affected by creatine supplementation are the same “fast-twitch” (Type II) fibers that commonly atrophy in older adults.38,39

Research suggests that when whey and creatine are taken together, they provide synergistic benefits that boost the effects of resistance training. In one study, men who supplemented with both whey and creatine showed greater gains in lean tissue mass and bench press strength than men who supplemented with whey alone or with placebo.25

Branched Chain Amino Acids

Whey protein is packed with branched chain amino acids (BCAAs), but these potent compounds are also available separately for added muscle support.

Three specific BCAAs, leucine, isoleucine, and valine, are essential amino acids that play important metabolic roles during exercise and in the maintenance and growth of skeletal muscle.

BCAAs account for 35% of the essential amino acids in muscle proteins and can serve as an energy source for muscle tissue during exercise. Leucine, the most metabolically active BCAA, has been well-documented to promote muscle tissue synthesis.40-43 Branched chain amino acids also reduce perceived exertion and mental fatigue during exercise.44


Glutamine—the most abundant amino acid in the body—is highly concentrated in the skeletal muscles that make movement possible. When scientists gave 2,000 mg of glutamine to nine healthy adults, eight out of the nine subjects experienced a four-fold increase in growth hormone output.45 Evidence suggests that after intense exercise, glutamine helps replenish muscle stores of glycogen,46 which serves as a ready source of fuel to power muscle action.

Vitamin D

Vitamin D helps preserve the same (Type II) muscle fibers that are prone to atrophy in aging adults. This suggests that low vitamin D levels in older individuals may contribute to poor muscle function (and bone formation). Supplemental vitamin D may reduce the incidence of sarcopenia (and osteoporosis)47—and therefore may contribute to the cognitive protection now associated with greater muscle strength through resistance exercise.


Carnitine is an amino acid derivative that transports fatty acids to the mitochondria to be used as fuel for energy production. It works by prompting mitochondria to produce cellular energy quickly and efficiently—helping to combat the age-related decrease in cellular energy and critically supporting exercise recovery.

Carnitine formulations may promote healthy muscle mass in older adults prone to sarcopenia,48 and it can protect against cognitive decline by boosting muscle strength. One novel form of carnitine known as propionyl-L-carnitine helps regulate levels of adenosine triphosphate (ATP)—the primary source of energy for all cellular processes—and can improve physical performance and reduce general fatigue.49,50

Omega-3 Fatty Acids

The omega-3 fatty acid EPA (eicosapentaenoic acid) preserves muscle mass under various physiological conditions.51 Both EPA and the omega-3 fatty acid DHA (docosahexaenoic acid) have anti-inflammatory effects, which scientists believe may help manage sarcopenia.52,53 In 2016, a placebo-controlled, double-blind trial concluded that 6 grams daily of fish oil may alleviate muscle soreness experienced after resistance training.54


D-ribose is a naturally occurring carbohydrate molecule that facilitates the production of ATP, the body’s energy currency.55 In studies of healthy athletes, supplying fatigued muscle cells with D-ribose quickly restored ATP levels to normal.56 By refilling depleted energy stores in muscle (and heart) tissue, D-ribose may help speed muscle recovery after high-intensity exercise.55


exercise and the brain

As we age, regular exercise becomes crucial for maintaining brain function and helping to inhibit neurodegenerative diseases. Exercise even promotes neurogenesis—the creation of new brain cells.

A new study demonstrates that, in those regularly participating in resistance (vs. aerobic) exercise, it’s the muscle-strength gains that mediate these cognitive benefits in aging individuals.

Various supplemental nutrients support the powerful benefits of resistance training to enhance cognition and memory and protect against age-related cognitive decline.

If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.


  1. Ploughman M. Exercise is brain food: the effects of physical activity on cognitive function. Dev Neurorehabil. 2008;11(3):236-40.
  2. Lista I, Sorrentino G. Biological mechanisms of physical activity in preventing cognitive decline. Cell Mol Neurobiol. 2010;30(4):493-503.
  3. Van der Borght K, Kobor-Nyakas DE, Klauke K, et al. Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis. Hippocampus. 2009;19(10):928-36.
  4. Pereira AC, Huddleston DE, Brickman AM, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007;104(13):5638-43.
  5. Linkis P, Jorgensen LG, Olesen HL, et al. Dynamic exercise enhances regional cerebral artery mean flow velocity. J Appl Physiol (1985). 1995;78(1):12-6.
  6. Querido JS, Sheel AW. Regulation of cerebral blood flow during exercise. Sports Med. 2007;37(9):765-82.
  7. Floel A, Ruscheweyh R, Kruger K, et al. Physical activity and memory functions: are neurotrophins and cerebral gray matter volume the missing link? Neuroimage. 2010;49(3):2756-63.
  8. Geda YE, Roberts RO, Knopman DS, et al. Physical exercise, aging, and mild cognitive impairment: a population-based study. Arch Neurol. 2010;67(1):80-6.
  9. Mavros Y, Gates N, Wilson GC, et al. Mediation of Cognitive Function Improvements by Strength Gains After Resistance Training in Older Adults with Mild Cognitive Impairment: Outcomes of the Study of Mental and Resistance Training. Journal of the American Geriatrics Society. 2016.
  10. Du J, Li G, Gao YL, et al. [Influencing factors on healthy life expectancy in adults in Beijing]. Zhonghua Liu Xing Bing Xue Za Zhi. 2016;37(8):1087-90.
  11. Roth SM, Ferrell RF, Hurley BF. Strength training for the prevention and treatment of sarcopenia. J Nutr Health Aging. 2000;4(3):143-55.
  12. Nagamatsu LS, Handy TC, Hsu CL, et al. Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment. Arch Intern Med. 2012;172(8):666-8.
  13. Paillard T, Rolland Y, de Souto Barreto P. Protective Effects of Physical Exercise in Alzheimer’s Disease and Parkinson’s Disease: A Narrative Review. J Clin Neurol. 2015;11(3):212-9.
  14. Ma Q. Beneficial effects of moderate voluntary physical exercise and its biological mechanisms on brain health. Neurosci Bull. 2008;24(4):265-70.
  15. Available at: Accessed February 6, 2017.
  16. Jembrek MJ, Vlainic J. GABA Receptors: Pharmacological Potential and Pitfalls. Curr Pharm Des. 2015;21(34):4943-59.
  17. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25(6):295-301.
  18. Komulainen P, Pedersen M, Hanninen T, et al. BDNF is a novel marker of cognitive function in ageing women: the DR’s EXTRA Study. Neurobiol Learn Mem. 2008;90(4):596-603.
  19. Leifke E, Gorenoi V, Wichers C, et al. Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: cross-sectional data from a healthy male cohort. Clin Endocrinol (Oxf). 2000;53(6):689-95.
  20. Goldspink G. Mechanical signals, IGF-I gene splicing, and muscle adaptation. Physiology (Bethesda). 2005;20:232-8.
  21. Mastorakos G, Pavlatou M, Diamanti-Kandarakis E, et al. Exercise and the stress system. Hormones (Athens). 2005;4(2):73-89.
  22. Available at: Accessed February, 2017.
  23. Dangin M, Boirie Y, Guillet C, et al. Influence of the protein digestion rate on protein turnover in young and elderly subjects. J Nutr. 2002;132(10):3228s-33s.
  24. Hayes A, Cribb PJ. Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training. Curr Opin Clin Nutr Metab Care. 2008;11(1):40-4.
  25. Burke DG, Chilibeck PD, Davidson KS, et al. The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength. Int J Sport Nutr Exerc Metab. 2001;11(3):349-64.
  26. Campbell WW, Crim MC, Dallal GE, et al. Increased protein requirements in elderly people: new data and retrospective reassessments. Am J Clin Nutr. 1994;60(4):501-9.
  27. Karakelides H, Nair KS. Sarcopenia of aging and its metabolic impact. Curr Top Dev Biol. 2005;68:123-48.
  28. Young VR. Amino acids and proteins in relation to the nutrition of elderly people. Age Ageing. 1990;19(4):S10-24.
  29. Houston DK, Nicklas BJ, Ding J, et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008;87(1):150-5.
  30. Gaffney-Stomberg E, Insogna KL, Rodriguez NR, et al. Increasing dietary protein requirements in elderly people for optimal muscle and bone health. J Am Geriatr Soc. 2009;57(6):1073-9.
  31. Morais JA, Chevalier S, Gougeon R. Protein turnover and requirements in the healthy and frail elderly. J Nutr Health Aging. 2006;10(4):272-83.
  32. Morse MH, Haub MD, Evans WJ, et al. Protein requirement of elderly women: nitrogen balance responses to three levels of protein intake. J Gerontol A Biol Sci Med Sci. 2001;56(11): M724-30.
  33. Smith SA, Montain SJ, Zientara GP, et al. Use of phosphocreatine kinetics to determine the influence of creatine on muscle mitochondrial respiration: an in vivo 31P-MRS study of oral creatine ingestion. J Appl Physiol (1985). 2004;96(6):2288-92.
  34. Allen PJ. Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value? Neurosci Biobehav Rev. 2012;36(5):1442-62.
  35. Chrusch MJ, Chilibeck PD, Chad KE, et al. Creatine supplementation combined with resistance training in older men. Med Sci Sports Exerc. 2001;33(12):2111-7.
  36. Gotshalk LA, Volek JS, Staron RS, et al. Creatine supplementation improves muscular performance in older men. Med Sci Sports Exerc. 2002;34(3):537-43.
  37. Brose A, Parise G, Tarnopolsky MA. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol Sci Med Sci. 2003;58(1):11-9.
  38. Kalyani RR, Corriere M, Ferrucci L. Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases. Lancet Diabetes Endocrinol. 2014;2(10):819-29.
  39. Deschenes MR. Effects of aging on muscle fibre type and size. Sports Med. 2004;34(12):809-24.
  40. Koopman R, Verdijk L, Manders RJ, et al. Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am J Clin Nutr. 2006;84(3):623-32.
  41. Dardevet D, Sornet C, Balage M, et al. Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age. J Nutr. 2000;130(11):2630-5.
  42. Katsanos CS, Kobayashi H, Sheffield-Moore M, et al. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab. 2006;291(2):E381-7.
  43. Fujita S, Volpi E. Amino acids and muscle loss with aging. J Nutr. 2006;136(1 Suppl):277s-80s.
  44. Matsumoto K, Koba T, Hamada K, et al. Branched-chain amino acid supplementation attenuates muscle soreness, muscle damage and inflammation during an intensive training program. J Sports Med Phys Fitness. 2009;49(4):424-31.
  45. Welbourne TC. Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr. 1995;61(5):1058-61.
  46. Varnier M, Leese GP, Thompson J, et al. Stimulatory effect of glutamine on glycogen accumulation in human skeletal muscle. Am J Physiol. 1995;269(2 Pt 1):E309-15.
  47. Montero-Odasso M, Duque G. Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone. Mol Aspects Med. 2005;26(3):203-19.
  48. Malaguarnera M, Cammalleri L, Gargante MP, et al. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr. 2007;86(6):1738-44.
  49. Brevetti G, Perna S, Sabba C, et al. Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study. J Am Coll Cardiol. 1995;26(6): 1411-6.
  50. Vermeulen RC, Scholte HR. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Psychosom Med. 2004;66(2):276-82.
  51. Tisdale MJ. Clinical anticachexia treatments. Nutr Clin Pract. 2006;21(2):168-74.
  52. Roubenoff R. Catabolism of aging: is it an inflammatory process? Curr Opin Clin Nutr Metab Care. 2003;6(3):295-9.
  53. Fritsche K. Fatty acids as modulators of the immune response. Annu Rev Nutr. 2006;26:45-73.
  54. Tinsley GM, Gann JJ, Huber SR, et al. Effects of Fish Oil Supplementation on Postresistance Exercise Muscle Soreness. J Diet Suppl. 2016:1-12.
  55. Dodd SL, Johnson CA, Fernholz K, et al. The role of ribose in human skeletal muscle metabolism. Med Hypotheses. 2004;62(5):819-24.
  56. Hellsten Y, Skadhauge L, Bangsbo J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. Am J Physiol Regul Integr Comp Physiol. 2004;286(1):R182-8.

Frank Wilhelmi

Frank Wilhelmi

Frank Wilhelmi – Retired/consultant electronic engineer researches and reports practical strategies for optimizing health and fitness into advanced age. “I have a passion for living life to the fullest, and helping others to do the same.” A rapidly growing body of knowledge now enables us to extend our health and fitness decades beyond popular expectations.

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