This is Big – ALS reversed; if it proves repeatable

In this case, a 56 year-old woman with advanced ALS, is today playing Pickle Ball and functioning at normal physical and mental levels. after having degenerated to symptom-levels commensurate with near death. This was accomplished with a modern adaptation of a 1927 Nobel Prize-winning method for inducing a “Malarial Fever” to cure infections. From the study Abstract:

We report the first application of therapeutic fever to ALS using Computerized Brain-Guided Intelligent Thermofebrile Therapy (CBIT²). This fully noninvasive treatment, delivered through an FDA-approved computerized platform, digitally reengineers the 1927 Nobel Prize-recognized malarial fever therapy into a modern treatment guided by the Brain–Eyelid Thermoregulatory Tunnel. CBIT² induces therapeutic fever through synchronized hypothalamic feedback, activating heat shock proteins, which are known to restore proteostasis and neuronal function.

From the study Conclusions:

Following treatment by Dr. Marc Abreu in his private practice at the BTT Medical Institute in Aventura, Florida, USA, using CBIT² delivered through an FDA-approved computerized platform, this fatal trajectory was not merely slowed but fundamentally transformed, achieving the neurological, molecular, structural, and electrophysiological reversal of ALS. EMG revealed the disappearance of fibrillation and fasciculations, signifying the cessation of motor neuron death while tongue structure was restored and biomarkers shifted toward recovery, with reductions in neurofilament light chain and homocysteine levels, normalization of IL-10 (with levels prior to CBIT² linked to increased mortality), and a dramatic rise in HSP70 expression. Correspondingly, the patient progressed from walker dependence to restored gait, safe swallowing, improved respiration, enhanced speech, and cognition restored to a normal score. Most strikingly, she regained the ability to perform complex motor tasks, including walking unaided onto a golf green, sinking consecutive putts, playing pickleball, and swimming, signaling not only survival but a return to a full life once thought irretrievably lost. The absence of diagnostic evidence for ALS led to the discontinuation of all ALS-specific medications, an outcome previously unimaginable for ALS.

Later in the Conclusions:

Following treatment by Dr. Marc Abreu in his private practice at the BTT Medical Institute in Aventura, Florida, USA, using CBIT² delivered through an FDA-approved computerized platform, this fatal trajectory was not merely slowed but fundamentally transformed, achieving the neurological, molecular, structural, and electrophysiological reversal of ALS. EMG revealed the disappearance of fibrillation and fasciculations, signifying the cessation of motor neuron death while tongue structure was restored and biomarkers shifted toward recovery, with reductions in neurofilament light chain and homocysteine levels, normalization of IL-10 (with levels prior to CBIT² linked to increased mortality), and a dramatic rise in HSP70 expression. Correspondingly, the patient progressed from walker dependence to restored gait, safe swallowing, improved respiration, enhanced speech, and cognition restored to a normal score. Most strikingly, she regained the ability to perform complex motor tasks, including walking unaided onto a golf green, sinking consecutive putts, playing pickleball, and swimming, signaling not only survival but a return to a full life once thought irretrievably lost. The absence of diagnostic evidence for ALS led to the discontinuation of all ALS-specific medications, an outcome previously unimaginable for ALS.

Now we wait to see if it allowed into practice as an approved therapy that works consistently, rather than killing the patients. https://pmc.ncbi.nlm.nih.gov/articles/PMC12651036/#abstract1.

To Your Greater Health and Fitness – and Longevity,

Frank