Frank’s Column
Frank’s Column
A Good Cover Article on Klotho and Aging
In Greek Mythology Clotho is the one of the Three Fates or Moirai who spins the thread of human life; in our biology Klotho is a trans-membrane receptor structure, parts of which also circulate in our blood, that influences lifespan in many ways. For those who want to...
Icariin Restores Gut Biome to Youthful Nature (In Old Mice)
Animal research shows that restoring the aged gut biome in old mice to that of a young one improves many measures of physical and mental capability, seemingly making the animal age in reverse. This has been accomplished by Fecal Transplantation (FT), by use of...
Icariin – Potential Super Supplement: Good For Everything?
Aging is accompanied by rising pain levels in practically everything in our bodies. Mine happens to be focused on knees and neck. That recently sent me to look into the ingredients of the well-advertised "Relief Factor". Of the four ingredients, the only one I was not...
Great article on the Benefits of Dance as an Exercise Strategy
One of the many newsletters I take had this very readable article on the benefits of taking a dance class for the purpose of exercise. Learning new steps with a favorite partner or a new one can improve the way the brain works and improve balance and motor control...
New Hope for Reversing Cognitive Decline; Senolytics
A definitive mouse study shows that several forms of stress increase multiplication rates of brain immune cells, leading to early senescence in those cell populations, and that leads to damage of neurons and cognitive decline, potentially including Parkinson's,...
The Promise of iPSC Vesicles for Vertebral Disk Repair
Take any old skin cell (or a million or so), add the four Yamanaka Factors reversing it's/their age to make it/them into near embryonic stem cells (induced pluripotent mesenchymal stem cells or iMSCs), feed them and let them multiply, then harvest the signaling...
The State of Senolytic Drug Development and Deployment
Senolytic drugs (or compounds) are a promising tool for reducing the impact of aging, potentially pushing the onset of the diseases of aging out into the far future. So how far along are we to deploying this potential tool for the average citizen's benefit? There are...
A Comprehensive Longevity Supplement Worth Considering – “Core” by Novos Labs
There are many individual supplements on the market claiming to promote Longevity and extended Healthspan, but I have been waiting for a product that would package key nutrients known to synergistically thwart the significant aging mechanisms at a reasonable price....
Definitive Science on Covid-19 and Benefit of Vitamin D Supplementation
I've been harping loud and long about supplementing vitamin D3 for optimal aging and for preventing severe damage or death from Covid-19. I typically use 5000-10,000 IU in summer, (because I don't get much sun) and 15,000 to 20,000 IU in winter, and have been doing so...
An Update on Cartilage Repair
Can an 81 year old gym rat regrow knee cartilage? It seems so. In July 2020, I was ramping up my leg-press load to see if I could get back to 10 plates per side (1000 lb including the sled). When I got to 8 plates per side on my last set that day, my left knee really...