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( Tricyclic antidepressant)
Tricyclic antidepressants (abbreviation TCA) are a class of antidepressant drugs first used in the 1950s. They are named after the drugs' molecular structure, which contains three rings of atoms (compare tetracyclic antidepressant). The first tricyclic antidepressant discovered was imipramine, which was discovered accidentally in a search for a new antipsychotic in the late 1950s. Antidepressant drugs in the tricyclic drug group (along with their actions as listed in MeSH) include Tricyclics are sometimes classified as tertiary amines and secondary amines. In general, the tertiary amines boost serotonin as well as nor-epinephrine (adrenergic) and produce more sedation, anticholinergic effects, and orthostatic hypotension.[2] The secondary amines act primarily on nor-epinephrine and tend to have a lower side-effect profile[3].
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Tricyclic antidepressant Subcategories
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Tricyclic Antidepressants by Jennifer Baxt
Tricyclic antidepressants are a type of antidepressant that has been used since the mid 1900s. Today, there are more than 30 different types of tricyclic antidepressants that are commonly used in cases of attention-deficit hyperactive disorder (ADHD)...
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