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Smoking is the most common method of consuming tobacco, and tobacco is the most common substance smoked. The agricultural product is often mixed with other additives^[8] and then pyrolyzed. The resulting vapors are then inhaled and the active substances absorbed through the alveoli in the lungs.^[9] The active substances trigger chemical reactions in nerve endings which hightens heart rate, memory, alertness,^[10] and reaction time.^[11] Dopamine and later endorphins are released, which are often associated with pleasure.^[12] As of 2000, smoking is practiced by some 1.22 billion people. Men are more likely to smoke than women,^[13] however the gender gap declines with younger age.^[14][15] The poor are more likely to smoke than the wealthy, and people of developing countries than those of developed countries.^[7]

Many smokers begin during adolescence or early adulthood. Usually during the early stages, smoking provides pleasurable sensations, serving as a source of positive reinforcement. After some individual have smoked for many years, the avoidance of withdrawal symptoms and negative reinforcement become the key motivations.

The history of smoking dates back to as early as 5000–3000 BC when the agricultural product began to be cultivated in South America; consumption later evolved into burning the plant substance either by accident or with intent of exploring other means of consumption.^[1] The practice worked its way into shamanistic rituals.^{[16][page&_160;needed]} Many ancient civilizations, such as the Babylonians, Indians and Chinese, burnt incense as a part of religious rituals, as did the Israelites and the later Catholic and Orthodox Christian churches. Smoking in the Americas probably had its origins in the incense-burning ceremonies of shamans but was later adopted for pleasure or as a social tool.^[2] The smoking of tobacco and various hallucinogenic drugs was used to achieve trances and to come into contact with the spirit world.

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