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( Thrombosis)
Thrombosis is the formation of a blood clot (thrombus) inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets and fibrin to form a blood clot, as the first step in repairing it (hemostasis) to prevent loss of blood. If that mechanism causes too much clotting, and the clot breaks free, a thrombus is formed.[1][2] When a thrombus occupies more than 75% of surface area of the lumen of an artery, blood flow to the tissue supplied is reduced enough to cause symptoms because of decreased oxygen (hypoxia) and accumulation of metabolic products like lactic acid. More than 90% of obstruction can result in anoxia, the complete deprivation of oxygen, and infarction, a mode of cell death. In classical terms, thrombosis is caused by abnormalities in one or more of the following (Virchow's triad) The formation of a thrombus is usually caused by Virchow's triad. To elaborate, the pathogenesis includes an injury to the vessel's wall (such as by trauma, infection, or turbulent flow at bifurcations); by the slowing or stagnation of blood flow past the point of injury (which may occur after long periods of sedentary behavior—for example, sitting on a long airplane flight); by a blood state of hypercoagulability (caused for example, by genetic deficiencies or autoimmune disorders).
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Thrombosis Subcategories
Thrombosis Articles
Systemic Lupus Erythematosus and The Symptoms by Lorna Darden
Lupus is a disorder of the immune system. It can affect people between the ages of 15-45 years of age. Lupus can develop later on in life as well. Lupus which is known as autoimmune disease turns your immune system against the body parts that it i...
Androgen-induced cerebral venous sinus thrombosis in a young body builder: case report
Androgen-induced cerebral venous sinus thrombosis in a young body builder: case report
Mohammad Ali Sahraian , Mahmood Mottamedi , Amir Reza Azimi and Babak Moghimi
Department of Neurology, Sina Hospital, Tehran University of ...
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