|
( Tetracycline)
D(AU) D(US) It works by inhibiting action of the prokaryotic 30S ribosome, by binding the 16S rRNA thereby blocking the aminoacyl-tRNA. However, bacteria strains can acquire resistance against tetracycline and its derivates by encoding a resistance operon. In eukaryotic cells, toxicity may be the result of inactivation of mitochondrial 30S ribosomes. The tetracyclines are a large family of antibiotics that were discovered as natural products by Benjamin Minge Duggar and first described in 1948.[1] Tetracycline was then discovered by Lloyd Conover in the research departments of Pfizer. The patent for tetracycline, U.S. Patent 2,699,054&_160;, was first issued in 1950. However, Nubian mummies have been studied in the 1990s and were found to contain significant levels of tetracycline; there is evidence that the beer brewed at the time could have been the source.[2] Tetracycline sparked the development of many chemically altered antibiotics and in doing so has proved to be one of the most important discoveries made in the field of antibiotics. It is used to treat many gram-positive and gram-negative bacteria and some protozoa. It, like some other antibiotics, is also used in the treatment of acne.
|
Tetracycline Subcategories
Tetracycline Articles
|
| 
