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( Statin) The statins (or HMG-CoA reductase inhibitors) form a class of hypolipidemic drugs used to lower cholesterol levels in people with or at risk of cardiovascular disease. They lower cholesterol by inhibiting the enzyme HMG-CoA reductase, which is the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis. Inhibition of this enzyme in the liver stimulates LDL receptors, resulting in an increased clearance of low-density lipoprotein (LDL) from the bloodstream and a decrease in blood cholesterol levels. The first results can be seen after one week of use and the effect is maximal after four to six weeks.

The first agent isolated was mevastatin (ML-236B), a molecule produced by Penicillium citrinum. The pharmaceutical company Merck & Co. showed an interest in the Japanese research in 1976, and isolated lovastatin (mevinolin, MK803), the first commercially marketed statin, from the mold Aspergillus terreus. Dr Endo was awarded the 2006 Japan Prize for his work on the development of statins.

Statins, the most potent cholesterol-lowering agents available, lower LDL cholesterol (so-called "bad cholesterol") by 30–50%.^[2] However, they have less effect than the fibrates or niacin in reducing triglycerides and raising HDL-cholesterol ("good cholesterol"). Professional guidelines generally require that the patient has tried a cholesterol-lowering diet before statin use is considered; statins or other pharmacologic agents may then be recommended for patients who do not meet their lipid-lowering goals through diet and lifestyle approaches.

The indications for the prescription of statins have broadened over the years. Initial studies, such as the Scandinavian Simvastatin Survival Study (4S), supported the use of statins in secondary prevention for cardiovascular disease, or as primary prevention only when the risk for cardiovascular disease was significantly raised (as indicated by the Framingham risk score).^[3] Indications were broadened considerably by studies such as the Heart Protection Study (HPS), which showed preventative effects of statin use in specific risk groups, such as diabetics. The ASTEROID trial, published in 2006, using only a statin at high dose, achieved lower than usual target calculated LDL values and showed disease regression within the coronary arteries using intravascular ultrasonography.^[4]

Statin Subcategories Statin Articles Coping with Rosacea and It's Devastating Effects by Valerie Garner What are the symptoms of rosacea? If you experience any of the following signs, you should consult a dermatologist right away. 1) Red or inflamed areas on the cheeks, forehead, nose, or chin 2) Visible blood vessels in the facial area or “spider... High Cholesterol: The HIDDEN Cause, and 7 Must-Know Dietary Tips! by Christine Kaczmar If you’re like me, you probably see at least one daily television commercial for Lipitor, the most popular cholesterol-lowering medication. Believe it or not, 16 million Americans are now taking Lipitor, costing each person $900-$1200 per ... Statin Dangers: This Cholesterol-Lowering Fad Has 7 Side Effects That Can Imperil Your Life by Jeff Popick media@jeffpopick.com. Best regards Jeff Popick http://www.JeffPopick.com Statin Dangers: This Cholesterol-Lowering Fad Has 7 Side Effects That Can Imperil Your Life High cholesterol and heart disease kill 1,000,000 Americans eve... Statins! The Magic Pill? by Jamesina Goulbourne What are Statins? Do you recognise any of these drugs? Zocor (Simvastatin), Lipitor (Atorvastatin), Mevacor (Lovastatin), Pravacol (pravastatin), Lescol (fluvastatin), Crestor (Rosuvastatin) are all generic names for the statin brand... 3 Simple Steps To A Life Free From the Devastating Symptoms of Fibromyalgia by Hailey Harris thkeharris@msn.com. Best regards Hailey Harris http://www.ridfibromyalgia.com 3 Simple Steps To A Life Free From the Devastating Symptoms of Fibromyalgia It can be difficult to rid yourself of the symptoms of fibromyalgia that a... The link between heart disease & cholesterol - fact or fallacy? by Craig Burton Heart disease is the number one killer in the world. One out of every two men and one out of every three women currently develop heart disease. The UK has one of the highest rates of death from heart disease in the world - one British adult dies from... Preventing Pharmaceutical-Induced Nutritional Deficiencies by Frederic Vagnini, MD, and Barry Fox, PhD LE Magazine March 2006 Preventing Pharmaceutical-Induced Nutritional Deficiencies By Frederic Vagnini, MD, and Barry Fox, PhD While pharmaceuticals have lifesaving benefits, many of these medications can have serious side eff... Heart supplements that will energize your body and reduce the side effects of statin drugs. by Gene Millen If your “get up and go got up and went” these heart supplements are just what you’ve been looking for. If you are taking any of the statin family of drugs such as Lipitor, Zocor or Crestor to lower your cholesterol you should not be without CoQ... Does simvastatin stimulate bone formation in vivo? Does simvastatin stimulate bone formation in vivo? Dietrich von Stechow1 , Susan Fish2 , Dror Yahalom2 , Itai Bab2, 3 , Michael Chorev2 , Ralph Müller4 and... Age-related changes in Serum Growth Hormone, Insulin-like Growth Factor-1 and Somatostatin in System Lupus Erythematosus Age-related changes in Serum Growth Hormone, Insulin-like Growth Factor-1 and Somatostatin in System Lupus Erythematosus Charles W Denko1 and Charles J Malemud2 1Department of Medicine/Division...