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( Senescence)
Senescence refers to the biological processes of a living organism approaching an advanced age (i.e., the combination of processes of deterioration which follow the period of development of an organism). The word senescence is derived from the Latin word senex, meaning "old man" or "old age" or "advanced in age". Senescence of the organism gives rise to the Gompertz-Makeham law of mortality, which says that mortality rate rises rapidly with age. Some animals, such as some reptiles and fish, age slowly. Some even exhibit "negative senescence", in which mortality falls with age, in disagreement with the Gompertz-Makeham "law".[1] The process of senescence is complex, and may derive from a variety of different mechanisms and exist for a variety of different reasons. However, senescence is not universal, and scientific evidence suggests that cellular senescence evolved in certain species as a mechanism to prevent the onset of cancer. In a few simple species, senescence is negligible and cannot be detected. All such species have no "post-mitotic" cells; they reduce the effect of damaging free radicals by cell division and dilution. Such species are not immortal, however, as they will eventually fall prey to trauma or disease. Moreover, average lifespans can vary greatly within and between species. This suggests that both genetic and environmental factors contribute to ageing.
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Senescence Subcategories
Senescence Articles
Delaying Age-related Functional Decline - A Multi-Pronged Approach - Part 1: Nutrition by Frank Wilhelmi
I don’t think I was the first to use the expression ‘age-related functional decline’, but I think it an excellent descriptive summary of what happens as we age. Aging, as we experience it, is the result of many related physiological processes slow...
Moderate exercise may attenuate some aspects of immunosenescence
Moderate exercise may attenuate some aspects of immunosenescence
Nadzieja Drela1 , Ewa Kozdron2 and Piotr Szczypiorski3
1Department of Immunology, Warsaw University, Warsaw, Poland
The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells
The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells
Natalia Martinez1 , Bettina Drescher2 , Heidemarie Riehle1 , Claire Cullmann
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