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( Plague (disease))
Plague is a deadly infectious disease caused by the enterobacteria Yersinia pestis (Pasteurella pestis). Plague is a zoonotic, primarily carried by rodents (notably rats) and spread to humans via fleas. Plague is notorious throughout history, due to the unprecedented scale of death and devastation it wrought. Plague is still endemic in some parts of the world. The epidemiological use of the term plague is currently applied to bacterial infections that cause buboes, although historically the medical use of the term plague has been applied to pandemic infections in general. Plague is often synonymous with "bubonic plague" but this only describes one of its manifestations. Other names have been used to describe this disease, such as "The Black Plague" and "The Black Death", the latter is now used primarily to describe the second, and most devastating pandemic of the disease. Bubonic plague is mainly a disease in rodents and fleas (Xenopsylla cheopis). Infection in a human occurs when a person is bitten by a flea that has been infected by biting a rodent that itself has been infected by the bite of a flea carrying the disease. The bacteria multiply inside the flea, sticking together to form a plug that blocks its stomach and causes it to begin to starve. The flea then voraciously bites a host and continues to feed, even though it cannot quell its hunger, and consequently the flea vomits blood tainted with the bacteria back into the bite wound. The bubonic plague bacterium then infects a new victim, and the flea eventually dies from starvation. Serious outbreaks of plague are usually started by other disease outbreaks in rodents, or a rise in the rodent population. In 1894, two bacteriologists, Alexandre Yersin of France and Shibasaburo Kitasato of Japan, independently isolated the bacterium in Hong Kong responsible for the Third Pandemic. Though both investigators reported their findings, a series of confusing and contradictory statements by Kitasato eventually led to the acceptance of Yersin as the primary discoverer of the organism. Yersin named it Pasteurella pestis in honor of the Pasteur Institute, where he worked, but in 1967 it was moved to a new genus, renamed Yersinia pestis in honor of Yersin. Yersin also noted that rats were affected by plague not only during plague epidemics but also often preceding such epidemics in humans, and that plague was regarded by many locals as a disease of rats villagers in China and India asserted that, when large numbers of rats were found dead, plague outbreaks in people soon followed.
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