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( Non-alcoholic fatty liver disease)
Non-alcoholic fatty liver disease (NAFLD) is fatty inflammation of the liver when this is not due to excessive alcohol use. It is related to insulin resistance and the metabolic syndrome, and may respond to treatments originally developed for other insulin resistant states (e.g. diabetes mellitus type 2), such as weight loss, metformin and thiazolidinediones.[1] Non-alcoholic steatohepatitis (NASH) is the most extreme form of NAFLD, which is regarded as a major cause of cryptogenic cirrhosis of the liver.[2] NASH was first described in 1980 in a series of patients of the Mayo Clinic.[3] Its relevance and high prevalence were recognized mainly in the 1990s. Some feel that NASH is a diagnosis of exclusion, and that many cases may be in fact be due to other causes.[4] Most patients with NAFLD have no or few symptoms. Infrequently, patients may complain of fatigue, malaise and dull right upper quadrant abdominal discomfort. Mild jaundice may, rarely, be noticed. More commonly NAFLD is diagnosed following abnormal liver function tests during routine blood tests. By definition, alcohol consumption of over 20 g/day (about 25ml/day) excludes the condition.[1] NAFLD is associated with insulin resistance and the metabolic syndrome (obesity, combined hyperlipidemia, diabetes mellitus (type II) and high blood pressure).[2][1]
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Non-alcoholic fatty liver disease Subcategories
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Alcoholism Is A Four Fold Progressive Disease by Robin Foote
Alcoholism is a disease of the body, thinking, emotions and spirit. Progressive damage to these four aspects interact in various ways such that a person is increasingly compelled to drink. Also, once drinking starts they cannot ‘always’ guarantee whe...
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