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( Ketoglutaric acid)
113.5 Its anion, Alpha-ketoglutarate (also called oxo-glutarate) is an important biological compound. It is the keto acid produced by de-amination of glutamate, and is an intermediate in the Krebs cycle. It is a key intermediate in the Krebs cycle, coming after isocitrate and before succinyl CoA. Anaplerotic reactions can replenish the cycle at this juncture by synthesizing alpha-ketoglutarate from transamination of glutamate, or through action of glutamate dehydrogenase on glutamate. Another function is to combine with nitrogen released in the cell, therefore preventing nitrogen overload.
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Ketoglutaric acid Articles
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