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( Ernest McCulloch) Dr. Ernest Armstrong McCulloch O.C., O.Ont., F.R.S.C. is a Canadian cellular biologist, best known for demonstrating – with James Till – the existence of stem cells.

McCulloch was born in Toronto, Canada, and was educated at Upper Canada College.

He studied medicine at the University of Toronto, graduating with an M.D. in 1948. Upon graduation, he began his education in research at the Lister Institute in London, England.

In 1957, McCulloch joined the Ontario Cancer Institute, incorporating the Princess Margaret Hospital, where he soon began collaborative research with James Till. His experience in hematology, when combined with Till's experience in biophysics, yielded a novel and productive combination of skills and interests.

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