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( Ernest McCulloch) Dr. Ernest Armstrong McCulloch (born 1926) O.C., O.Ont., F.R.S.C. is a Canadian cellular biologist, best known for demonstrating – with James Till – the existence of stem cells.

McCulloch was born in Toronto, Canada on 21 April, 1926, and was educated at Upper Canada College.

Ernest McCulloch received his MD in 1948 from the University of Toronto. Upon graduation, he began his education in research at the Lister Institute in London, England.

In 1957 he joined the newly formed Ontario Cancer Institute where the majority of his research focused on normal blood-formation and leukemia. Together with his colleague, Dr. J.E. Till, Dr. McCulloch created the first quantitative, clonal method to identify stem cells and used this technique for pioneering studies on stem cells. His experience in hematology, when combined with Till's experience in biophysics, yielded a novel and productive combination of skills and interests.

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