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( Cardiac amyloidosis)
Cardiac amyloidosis is a medical disorder, a type of amyloidosis, caused by deposits of an amyloid protein in the heart tissue, resulting in decreased heart function. Different types of amyloidosis are caused by different types of proteins, such as "AL" and "AA." In cardiac amyloidosis there may be associated conduction disturbances (changes in the way the cardiac electrical impulse is transmitted through the heart). Cardiac amyloidosis usually occurs during primary or AL amyloidosis. Primary amyloidosis usually accompanies multiple myeloma, a blood disorder in which too much of a certain type of protein is produced. This excess protein is deposited in the heart and in other organs such as the kidney. Deteriorating kidney function also occurs. The heart is less often compromised by secondary or AA amyloidosis. A type of secondary amyloidosis that involves the heart is senile amyloidosis. It is caused by overproduction of a protein different from both the AA and AL types. This protein is deposited mainly in the heart, but can also infiltrate blood vessels. Senile cardiac amyloidosis is becoming more common as the average age of the population increases.
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