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( Baltimore classification)
The Baltimore classification is a virus classification system which groups viruses into families depending on their type of genome (DNA, RNA, single-stranded (ss), double-stranded (ds) etc.) and their method of replication. Classifying viruses according to their genome means that those in a given category will all behave in much the same way, which offers some indication of how to proceed with further research. In short This type of virus usually must enter the host nucleus before it is able to replicate. Furthermore, these viruses require host cell polymerases to replicate the viral genome and hence are highly dependent on the cell cycle. Proper infection and production of progeny requires that the cell be in replication as that is when the cell's polymerases are active. The virus may induce the cell to forcefully undergo cell division, and chronically, this may lead to transformation of the cell and ultimately, cancer. Examples include Herpesviridae, Adenoviridae and Papovaviridae. There is only one well studied example in which a class 1 virus is not replicating within the nucleus, that is the Poxvirus family, a highly pathogenic virus that infects vertebrates and includes the smallpox virus.
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