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( Arginine) Arginine (abbreviated as Arg or R)[1] is an a-amino acid. The L-form is one of the 20 most common natural amino acids. Its codons are CGU, CGC, CGA, CGG, AGA, and AGG. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. Infants are unable to meet their requirements and thus arginine is nutritionally essential for infants. Arginine was first isolated from a lupin seedling extract in 1886 by the Swiss chemist Ernst Schultze.

Arginine consists of a 4-carbon aliphatic straight chain, the distal end of which is capped by a complex guanidinium group. With a pKa of 12.48, the guanidinium group is positively charged in neutral, acidic and even most basic environments, and thus imparts basic chemical properties to arginine. Because of the conjugation between the double bond and the nitrogen lone pairs, the positive charge is de-localized, enabling the formation of multiple H-bonds.

Arginine is a conditionally essential amino acid, meaning most of the time it can be manufactured by the human body, and does not need to be obtained directly through the diet. The biosynthetic pathway however does not produce sufficient arginine, and some must still be consumed through diet. Individuals who have poor nutrition or certain physical conditions may be advised to increase their intake of foods containing arginine. Arginine is found in a wide variety of foods, including[2]

Arginine is synthesized from citrulline by the sequential action of the cytosolic enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL). This is energetically costly, as the synthesis of each molecule of argininosuccinate requires hydrolysis of adenosine triphosphate (ATP) to adenosine monophosphate (AMP); i.e., two ATP equivalents.

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Arginine Articles

Top Seven Muscle Building Supplements by Dimitri Papalexiou

Just about everyone wants to have a more attractive, toned, muscular body, and most folks would like a partner that has one too. This is not all about vanity though, having a slim, muscled body is also good for your health, longevity and your self...

Male Sexual Health by Ignacio Ceja
Quite often, male sexual health and erectile function come down to two things, testosterone and circulation.

Testosterone is a steroid hormone produced by the testicles. It is responsible for producing and maintaining male secondary sexual c...

L-Arginine - A Supplement for Health and Increased Sex Drive by sacha tarkovsky
L-Arginine has been a favorite of bodybuilders for many years, but is also being taken by many for its general health benefits and the fact that it is one of the best supplements to boost sex drive naturally and is nicknamed “natures Viagra”

...

NO2 - Nitric Oxide Supplements for Bodybuilding by Chester Ku-Lea
Nitric Oxide, a key molecule manufacturered by the body, causes vasodilation (an expansion of the internal diameter of blood vessels), which in turn leads to increased blood flow, oxygen transport, delivery of nutrients to skeletal muscle and a red...

Know Your Bodybuilding Supplement - L-Arginine by Rick Mitchell

Arginine is a semi-essential amino acid that the body cannot make naturally. It is found in nuts, seeds, chocolate and raisins.

Arginine is used by the body in the execution of many important physiological processes including h...

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